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	Home Degrees Option Areas and Courses:   Show All    Admissions Faculty Facilities and Resources News UMASSMARINE Newsletter Links Contact Us Directions		Faculty Professor SINGH, BAL RAM (Dartmouth) Professor of Chemistry and Biochemistry; Senior Fellow, School for Marine Science and Technology     Phone: (508) 999-8588     Alt. Phone: (508) 910-6318     Email: bsingh@umassd.edu Teaching the following courses: Biochemistry Laboratory **Disclaimer: Condensed CVs for the School of Marine Sciences. For a full CV, please contact the professor.** Education: 1987 - 1990 - Postdoctoral Fellow, University of Wisconsin - Madison 1987 - Ph.D., Texas Tech University 1979 & 1982 - M.Phil and M.Sc., Jawaharlal Nehru University, India 1977 - B.Sc., Avadh University, India Professional History: 6/90 – present - Assistant, Associate & Full Professor, University of Massachusetts, Dartmouth 6/90 – present - Fellow and Senior Fellow, School for Marine Science and Technology 1996 - 1997 - Visiting Associate Professor, Harvard Medical School 1991 - Visiting Professor, Georgetown University 1989 – 1990 - Assistant Scientist, University of Wisconsin 1988 - 1989 - Assistant and Associate Researcher, University of Wisconsin 1987 – 1988 - Research Associate, University of Wisconsin Current Research Support: Structure - function relationship of proteins: molecular mechanism of clostridial neurotoxin action, glutathione transferase as biomarker of marine environmental pollution., Camille and Henry Dreyfus Foundation, $60,000, 1 June 1997 - 31 May 2002 Mechanism botulinum neurotoxin action, NIH, $510,000, 1 July 1995 - 30 June 2001 Use of Molecular Genetics to reduce pesticide dependence in cranberry production, USDA - $112,502, 1 July 1999 - 30 June 2001 Protein Characterization, Private Company, $240,000, 1 Sept. 1999 - 31 Aug. 2002 Selected Publications: Singh, B. R., Fu, F. - N. and Ledoux, D. N. (1994) Crystal versus solution structure of superantigenic staphylococcal enterotoxins. Nature Structural Biology 1, 358 - 360. Singh, B. R. and Tu, A. (1996) Natural Toxins II: Structure, Mechanism of Action and Detection, Plenum Press, New York. Ge, J. and Singh, B. R. (1996) Physico - chemical characterization of glutathione - s - transferase purified from oyster, Crassostrea virginica. J. Marine Biotech. 4, 150 - 154. Fu, F. - N., Lomneth, R. B., Cai, S. and Singh, B. R. (1998) Role of zinc in the toxic structure and activity of botulinum neurotoxin. Biochemistry 37, 5267 - 5278. Blanchette, B. N. and Singh, B. R. (1999) Purification and characterization of the glutathione - S - transferases from the northern quahog, Mercenaria mercinaria. J. Marine Biotechnol., 1, 74 - 80. Cai, S., Sarkar, H. K. and Singh, B. R. (1999) Enhancement of the endopeptidase activity of botulinum neurotoxin by its associated proteins and dithiothreitol. Biochemistry, 38, 6903 - 6910. Singh, B. R. (2000) Intimate details of the most poisonous poison. Nature Structural Biology, 8, 617 - 619.
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